Si Belle BTX

From hydration to expression-line care

Conventional skin boosters focus on hydration and skin conditioning. Si Belle BTX introduces a peptide-based concept focused on expression-related wrinkles and the biological pathways associated with contraction signals.

The formulation concept combines botulinum-inspired peptide mechanisms with a skin-booster format. The product packaging carries the line “Less Resistance, More Resilience.”

Composition and primary functions

All five featured peptide ingredients are presented for anti-wrinkle application.

How the peptide pathways are described

Acetylcholine release depends on the SNARE complex. The catalogue explains several peptide mechanisms at different points along the neurotransmission and muscle-contraction pathway.

Recombinant peptide technology

The catalogue describes sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1) as a recombinant, highly purified protein comprising the light chain of botulinum toxin. SNAP-25 is identified as the shared biological target, with direct enzymatic cleavage of the SNARE protein complex.

The source diagram compares a conventional heavy-chain + light-chain structure with a delivery-peptide + light-chain structure. Oligopeptide-91 is described as the delivery tag in the peptide concept.

Arginine/Lysine Polypeptide

A biomimetic peptide inspired by compounds found in cone-snail venom. The proposed activity concerns sodium channels on the surface of muscle fibres.

Following acetylcholine release and receptor binding, rapid sodium-ion influx is involved in the electrical signal that supports muscle contraction. The catalogue schematic places the peptide interaction at the sodium-channel stage.

Acetyl Hexapeptide-8 and Acetyl Octapeptide-3

These SNAP-25-derived peptides compete in SNARE-complex formation and reduce acetylcholine release. Acetyl Octapeptide-3 is described as a Hexapeptide-8 derivative with higher biological activity in the cited material.

Pentapeptide-18

Pentapeptide-18 is described through enkephalin-receptor binding and reduced calcium-channel opening, followed by reduced acetylcholine release.

The catalogue includes third-party images comparing Pentapeptide-18, Acetyl Hexapeptide-8 and their combination over 28 days.

Peptide concept compared with other formats

Analytical and cellular assays included

The brochure presents SDS-PAGE qualitative / quantitative analysis and cellular viability assays in human epidermal cells and human dermal fibroblasts.

No cytotoxicity was observed at ingredient concentrations of 10 ppm or below compared with control in the reported assays.

Four-week human evaluation reported

The catalogue reports a nasolabial-fold evaluation conducted by H&Bio Co., Ltd. / Korea Skin Clinical Research Center, with 21 subjects and a 1 ppm study formulation over four weeks.

The mean age was 49.43 ± 4.43 years, with a range of 41–54 years. The brochure reports wrinkle improvement and no adverse skin reactions during the study period.